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In addition, amlodipine effectively prevents protein glycation, as evidenced by a reduction in amyloid-beta structure, Amadori products, and advanced glycation end products (AGEs)

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We further determined that the underlying mechanisms of the protective effects by TB001 involve enhancing lipid metabolism related pathways and inhibiting key pro-fibrotic pathways, such as TGF-1/Smad2/3/Twist and PKC signaling